Poster Awards Competition

The flavonolignans silybin A and silybin B from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations
Scott J. Brantley, University of North Carolina at Chapel Hill; Nicholas H. Oberlies, Research Triangle Institute; David J. Kroll, North Carolina Central University; Mary F. Paine, University of North Carolina at Chapel Hill
Highly Reactive Cyclopentenone Isoprostanes Derived from Eicosapentaenoic Acid Exert Potent Anti-Inflammatory Effects Through Inhibition of NFκB Signaling
Joshua D. Brooks, Vanderbilt University; Ginger L. Milne, Vanderbilt University; Stephane C. Sanchez, Vanderbilt University; BethAnn McLaughlin, Vanderbilt University; Jason D. Morrow, Vanderbilt University
Hepatoprotective Role of Interleukin-4 in Acetaminophen-Induced Liver Injury by Positively Regulating Glutathione Synthesis
Pauline M. Ryan, Laboratory of Molecular Immunology, National Heart,Lung and Blood Institute, National Institutes of Health, DHHS; Mohammed Bourdi, Laboratory of Molecular Immunology, National Heart,Lung and Blood Institute, National Institutes of Health, DHHS; Mala Chakraborty, Laboratory of Molecular Immunology, National Heart,Lung and Blood Institute, National Institutes of Health, DHHS; Steven B Yee, Laboratory of Molecular Immunology, National Heart,Lung and Blood Institute, National Institutes of Health, DHHS; Lance R Pohl, Laboratory of Molecular Immunology, National Heart,Lung and Blood Institute, National Institutes of Health, DHHS
3-Methylindole is a Potential Carcinogen That Induces DNA Damage
Mohammad Shadid, University of Utah; N.Shane Cutler, University of Utah; Jessica Weams, University of Utah; Jacob D. McDonald, Lovelace Respiratory Research Institute; Christopher A. Reilly, University of Utah; Garold S. Yost, University of Utah
ABCB1 and ABCG2 mediated Transport and Brain Distribution of Dasatinib
Ying Chen, University of Minnesota; Naveed M. Shaik, University of Minnesota; Zheng Yang, Bristol-Myers Squibb Company; Cliff Chen, Bristol-Myers Squibb Co.; William F. Elmquist, University of Minnesota
Involvement of Drug Transporters In the Skeletal Muscle Distribution of Statins
Michael J. Knauer, University of Western Ontario; Neha Khandekar, University of Western Ontario; Bradley L. Urquhart, University of Western Ontario; Henriette E. Meyer zu Schwabedissen, University of Western Ontario; Ute I. Schwarz, University of Western Ontario; Brenda F. Leake, Vanderbilt University Medical Center; Christopher J. Lemke, Vanderbilt University Medical Center; Richard B. Kim, University of Western Ontario; Rommel G. Tirona, University of Western Ontario
Induction of hepatic drug-metabolizing enzymes by Ginkgo biloba extract through PXR, CAR, and AhR-mediated pathways
Linhao Li, University of Maryland at Baltimore; Joseph D. Stanton, University of Maryland at Baltimore; Antonia H. Tolson, University of Maryland at Baltimore; Yuan Luo, University of Maryland at Baltimore; Hongbing Wang, University of Maryland at Baltimore
Regulation Of Cytochrome P450 3A Gene Expression In Pediatric Patients And By Glucocorticoids In Vitro
Christopher R. Orton, University of Utah; Robert Ward, University of Utah School of Medicine; Garold S. Yost, University of Utah
Circadian Expression Profiles of Drug Processing Genes and Transcription Factors in Mouse Liver
Yu-Kun Jennifer Zhang, University of Kansas Medical Center; Ronnie Yeager, University of Kansas Medical Center; Curtis D. Klaassen, University of Kansas Medical Center
Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronate towards the D-glucuronate pathway in isolated rat hepatocytes
Tom S. Chan, Centre Hospitalier de l`Université de Montréal; John X. Wilson, University at Buffalo: The State University of New York; Subajini Selliah, Centre Hospitalier de l`Université de Montréal; Raymond Poon, Health Canada; Claudia Zwingmann, Centre Hospitalier de l`Université de Montréal; Marc Bilodeau, Centre Hospitalier de l`Université de Montréal; Peter J. O'Brien, University of Toronto
CYP4F2 is a Vitamin K1 Hydroxylase: A Molecular Explanation for Altered Warfarin Dose in Carriers of the Functionally Defective V433M Variant
Matthew G. McDonald, University of Washington; Mark J. Rieder, University of Washington; Mariko Nakano, University of Washington; Clara Hsia, University of Washington; Allan E. Rettie, University of Washington
Functional analysis of genetic variants in the proximal promoter of nucleoside transporter families, SLC28A and SLC29A
Sook Wah Yee, University of California San Francisco; James E. Shima, University of California San Francisco; Stephanie Hesselson, University of California San Francisco; Loan Nguyen, University of California San Francisco; Pui-Yan Kwok, University of California San Francisco; Nadav Ahituv, University of California San Francisco; Kathleen M. Giacomini, University of California San Francisco
New Anti-Alzheimer's Disease Agents: Chemical, Biological and Metabolic Properties
Xueying Zheng, Human BioMolecular Research Institute; Senait Ghirmai, Human BioMolecular Research Institute; John Cashman, Human BioMolecular Research Institute
The polymorphic UGT2B7 enzyme is primarily responsible for the glucuronidation of antiretroviral drugs efavirenz (EFV) and zidovudine (AZT)
Anne-Sophie Bélanger, Laval University, Pharmacogenomics Laboratory; Rajeev Mehlotra, Center for Global Health and Diseases, Case Western Reserve University; Vincent Ménard, Laval University, Pharmacogenomics Laboratory; Chantal Guillemette, Laval University, Canada Research Chair in Pharmacogenomics
Defining the in vivo role for cytochrome b5 in cytochrome P450 mediated drug metabolism through the global deletion of cytochrome b5
Robert D. Finn, Cancer Research UK Molecular Pharmacology Unit; Sebastein Ronseaux, Cancer Research UK Molecular Pharmacology Unit; Lesley A. McLaughlin, Cancer Research UK Molecular Pharmacology Unit; Colin J. Henderson, Cancer Research UK Molecular Pharmacology Unit; C. Roland Wolf, Cancer Research UK Molecular Pharmacology Unit
Pinoline Metabolism Is Governed by CYP2D6 Status
Xiling Jiang, University at Buffalo, The State University of New York; Hongwu Shen, The State University of New York at Buffalo; Ai-Ming Yu, University at Buffalo, SUNY
Structures of Human Cytochrome P450 2E1 with Inhibitors 4-Methylpyrazole and Indazole
Kathleen M. Meneely, The University of Kansas; Patrick R. Porubsky, The University of Kansas; Emily E. Scott, The University of Kansas
A novel mouse model to study the interplay between CYP3A and P-glycoprotein
Robert A.B. van Waterschoot, The Netherlands Cancer Institute; Jurjen S. Lagas, The Netherlands Cancer Institute; Els Wagenaar, The Netherlands Cancer Institute; Cornelia M.M. van der Kruijssen, The Netherlands Cancer Institute; Antonius. E. van Herwaarden, The Netherlands Cancer Institute; Jos H. Beijnen, Slotervaart Hospital; Alfred. H. Schinkel, The Netherlands Cancer Institute
The Clock Makes the Poison?
Louisa A. Hooven, Oregon State University; Shawn Butcher, Oregon State University; Jaga Giebultowicz, Oregon State University
Novel Mutations of the Human Flavin-Containing Monooxygenase 3 (FMO3) Gene Associated with Trimethylaminuria
Meike S. Motika, Human BioMolecular Research Institute; Jun Zhang, Human BioMolecular Research Institute; Xueying Zheng, Human BioMolecular Research Institute; Kirstin Riedler, Human BioMolecular Research Institute; John R. Cashman, Human BioMolecular Research Institute
Tumor Pharmacokinetics of SN 28049 In Mice
Pradeep B. Lukka, The University of Auckland; Philip Kestell, The University of Auckland; James W. Paxton, The University of Auckland; Bruce C. Baguley, The University of Auckland
Novel transgenic mouse model to study human OATP1B1-mediated pharmacokinetics in vivo
Evita van de Steeg, The Netherlands Cancer Institute; Els Wagenaar, The Netherlands Cancer Institute; Corina M.M. van der Kruijssen, The Netherlands Cancer Institute; Johanna E.C. Burggraaff, The Netherlands Cancer Institute; Kathryn E. Kenworthy, GlaxoSmithKline; Alfred H. Schinkel, The Netherlands Cancer Institute
Pharmacokinetic Drug-Drug Interactions of Indolealkylamines
Hongwu Shen, The State University of New York at Buffalo; Xiling Jiang, University at Buffalo, The State University of New York; Ai-Ming Yu, University at Buffalo, SUNY
Predicting The Dose-Dependent Effects Of Itraconazole And Its Metabolites On CYP3A4 In Vivo
Ian E. Templeton, University of Washington; Kenneth E. Thummel, University of Washington; Kent L. Kunze, University of Washington; Nina Isoherranen, University of Washington
Mechanistic Modeling of the Time and Concentration Dependence of Cytochrome P450 3A4 (CYP3A4) Induction in Human Hepatocytes (HH)
R. M. Strother, Indiana University School of Medicine; T. Heinke, Indiana University School of Medicine; Edward LeCluyse, CellzDirect, Inc.; Stephen S. Ferguson, CellzDirect; Steven A. Wrighton, Eli Lilly and Company; Steve Hall, Eli Lilly and Company
Time dependent inhibition of CYP3A by diltiazem: The role of the sequentially-formed metabolite, N-hydroxydesmethyl diltiazem, in MI complex formation
Kelsey L. Hanson, University of Washington; Ping Zhao, CDER, FDA; Kantipudi N. Babu, University of Washington; Wendel L. Nelson, University of Washington; Tom F. Kalhorn, University of Washington; Kent L. Kunze, University of Washington
The effect of inhibitors, structurally related to UDP-glucuronic acid, on human recombinant UGT1A10
Anna Mazur, Univ of Arkansas for Med Sci; Stacie Bratton, Univ of Arkansas for Med Sci; Anna Gallus-Zawada, Univ of Arkansas for Med Sci; Grover Paul Miller, Univ of Arkansas for Med Sci; Moshe Finel, University of Helsinki; Anna Radominska-Pandya, Univ of Arkansas for Med Sci
Stereoselective metabolism of fluoxetine results in the irreversible inhibition of CYP2C19 thru the formation of an MI complex
Brooke M. VandenBrink, University of Washington; Kantipudi N. Babu, University of Washington; Nina Isoherranen, University of Washington; Wendel L. Nelson, University of Washington; Thomas F. Kalhorn, University of Washington; Kent L. Kunze, University of Washington
Mouse Flavin-Containing Monooxygenase (FMO) distribution in the CNS
Stella Gagliardi, Human BioMolecular Research Institute; Paolo Ogliari, Neurological Institute “C. Mondino”; Manuel Corato, Neurological Institute “C. Mondino”; Emanuela Cova, Neurological Institute “C. Mondino”; Mauro Ceroni, Neurological Institute “C. Mondino”; John R. Cashman, Human BioMolecular Research Institute; Cristina Cereda, Neurological Institute “C. Mondino”
Dioxin responsive element cluster (DREC) on Cyp1a1_1a2 represents a common AHR regulatory domain of Cyp1a1 and Cyp1a2 genes, and is protective in TCDD-induced toxicity
Manabu Nukaya, University of Wisconsin-Madison; Susan Moran, University of Wisconsin-Madison; Christopher A. Bradfield, University of Wisconsin-Madison
Hepatobiliary Disposition of Morphine and Generated Morphine 3-Glucuronide (M3G) in Sandwich-Cultured Rat Hepatocytes
Kristina K. Wolf, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Arlene S. Bridges, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Joseph W. Polli, GlaxoSmithKline, Inc.; Kenneth R. Brouwer, Qualyst, Inc.; Gary M. Pollack, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Kim L. R. Brouwer, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy
Thiol-detecting fluorescence probes for functional assays of organophosphonate hydrolase
Beilin Wang, Human BioMolecular Research Institute; Xueying Zheng, Human BioMolecular Research Institute; Karl Okolotowicz, Human BioMolecular Research Institute; Mary MacDonald, Human BioMolecular Research Institute; Gang Xia, Human BioMolecular Research Institute; John Cashman, Human BioMolecular Research Institute; Jun Zhang, Human BioMolecular Research Institute
Hepatobiliary Disposition of Troglitazone, Troglitazone Sulfate (TS), Troglitazone Glucuronide (TG), and Troglitazone Quinone (TQ) in Sandwich-Cultured Rat and Human Hepatocytes
Koji Abe, Daiichi-Sankyo Co., Ltd.; Tracy L. Marion, The University of North Carolina at Chapel Hill; Kim L. R. Brouwer, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy
Resolution of acute thioacetamide-induced liver injury in male BALB/c mice is associated with an up-regulation of hepatic energy metabolism
Sven Gottschalk, Université de Montreal; Tom S. Chan, Université de Montreal; Valérie-Ann Raymond, Université de Montreal; Dieter Leibfritz, University of Bremen; Claudia Zwingmann, Université de Montreal; Marc Bilodeau, Université de Montreal
Mitochondrial Over Expression of Human Equilibrative Nucleoside Transporter-1 Augments In Vitro Mitochondrial Toxicity of Fialuridine
Rajgopal Govindarajan, University of Washington; Christina Shadle, University of Washington; Hau Do, University of Washington; Jashvant Unadkat, University of Washington
Identification of a Metabolic Pathway Leading to Nevirapine-induced Skin Rash
Jie Chen, University ot Toronto; Jack Uetrecht, University ot Toronto
Disposition of Silymarin Flavonolignans in Isolated Perfused Gunn Rat Livers: Role of Phase II Metabolism and UGT1A1
Sonia R. Miranda, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Jin K. Lee, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Zhiming Wen, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Kim L.R. Brouwer, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Philip C. Smith, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Roy L. Hawke, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy
Gene expression of aldehyde dehydrogenases involves NF-E2-related factor-2 (Nrf2)
Ngome L. Makia, U. Louisville School of Medicine; K. Cameron Falkner, U. Louisville School of Medicine; Daniel J. Conklin, U. Louisville School of Medicine; Aruni Bhatnagar, U. Louisville School of Medicine; Russell A. Prough, U. Louisville School of Medicine
A CpG promoter sequence enhances expression of flavin containing monoxygenase (FMO) and green fluorescent protein (GFP) in BEAS-2B cells
Shannon Elizabeth Wenig, Oregon State University; Sharon K Krueger, Oregon State University; Marilyn C Henderson, Oregon State University; Lisbeth K Siddens, Oregon State University; Jonathan E VanDyke, Oregon State University; David E Williams, Oregon State University
A pharmacogenomics study of the human glucuronosyltransferase UGT1A4
Marie-Odile Benoit-Biancamano, Laval University, Canada Research Chair in Pharmacogenomics; Jean-Philippe Adam, Laval University, Canada Research Chair in Pharmacogenomics; Chantal Guillemette, Laval University, Canada Research Chair in Pharmacogenomics
High-throughput Determination of Phakellistatin 13 in Rat Plasma by Liquid Chromatography-tandem Mass Spectrometry, Following Protein Precipitation in The 96-well Filter Plate Format
Wen Jun, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Wei Hua, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Xie Rui, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Pan Yaju, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Fan Guorong, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Wu Yutian, ,School of Pharmacy, Second Military Medical University,Shanghai Key Laboratory for Pharmaceutical Metabolite Research
Functional Significance of Polymorphism in Aldo-Keto Reductase 1C2 in the Deactivation of Dihydrotestosterone
Ryan H. Takahashi, The University of British Columbia; Tom A. Pfeifer, The University of British Columbia; Thomas A. Grigliatti, The University of British Columbia; Ronald E. Reid, The University of British Columbia; K. Wayne Riggs, The University of British Columbia
Impact of P-glycoprotein and Mrp2 (Abcc2) on the pharmacokinetics of etoposide and its main metabolite, 4'-etoposide-glucuronide
Jurjen S. Lagas, The Netherlands Cancer Institute; Lin Fan, The Netherlands Cancer Institute; Jos H. Beijnen, Slotervaart Hospital; Olaf Van Tellingen, Netherlands Cancer Institute; Alfred. H. Schinkel, The Netherlands Cancer Institute
Molecular Determinants of Human OATP1B1 and OATP1B3 Transporter Substrate Specificity
Marianne K. DeGorter, University of Western Ontario; Rommel G. Tirona, University of Western Ontario; Richard B. Kim, University of Western Ontario
BCRP-Mediated Transport of Pemetrexed (Alimta) is pH-Dependent
Li Li, University of Minnesota; William F. Elmquist, University of Minnesota
Role of Mrp2 (Abcc2) in the Biliary Excretion of Silymarin Flavonolignans and their Glucuronide and Sulfate Conjugates in Isolated Perfused Rat Livers
Sonia R. Miranda, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Jin K. Lee, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Kim L.R. Brouwer, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Zhiming Wen, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Philip C. Smith, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Roy L. Hawke, The University of North Carolina at Chapel Hill Eshelman School of Pharmacy
OATP1B1-mediated transport of anticancer drugs gimatecan and BNP1350 can be inhibited by several classic BCRP and P-gp inhibitors
Evita van de Steeg, The Netherlands Cancer Institute; Roos L. Oostendorp, The Netherlands Cancer Institute; Corina M. M. van der Kruijssen, The Netherlands Cancer Institute; Jos H. Beijnen, Slotervaart Hospital; Alfred H. Schinkel, The Netherlands Cancer Institute; Jan H. Schellens, The Netherlands Cancer Institute
Proton Pump Inhibitor Use Is Associated With Decreased Intestinal Expression Of The Human Proton Coupled Folate Transporter (hPCFT)
Bradley L. Urquhart, The University of Western Ontario; Jamie C. Gregor, Disvision of Gastroenterology; Rommel G. Tirona, University of Western Ontario; Ute I. Schwarz, The University of Western Ontario; George K. Dresser, The University of Western Ontario; Nilesh Chande, Disvision of Gastroenterology; Jayesh Patel, Disvision of Gastroenterology; Richard B. Kim, The University of Western Ontario
Construction of a Functional Transporter Analysis System Using Lentivirus-Mediated Silencing of ABCG2 Gene in Caco-2 Cell line
Zhu Ze, College of Pharmacy, University of Houston; Ming Hu, College of Pharmacy, University of Houston