Mechanisms of Xenobiotic Toxicities

A Comparative Kinetic Study Of [14C]-Eugenol And [14C]-Methyleugenol Activation And Detoxification In Human, Mouse, And Rat Liver Fractions
Emmanuel Minet, British American Tobacco; Daniela Gentile, Charles River Laboratories; Clive Meredith, British American Tobacco; Nik Newland, British American Tobacco; Eian Massey, British American Tobacco
A Simple, Robust Automated Multiplexed Cell-Based Assay Process for the Assessment of Mitochondrial Dysfunction and Cytotoxicity
Bradley R. Larson, BioTek Instruments; Peter Banks, BioTek Instruments; Tracy Worzella, Promega Corporation; Timothy A. Moeller, Celsis In Vitro Technologies; Andrew Niles, Promega Corporation
A fluorescence based screening approach for determination of drug-phospholipid complex formation and prediction of phospholipidosis
Liping Zhou, Novartis Institutes for Biomedical Research Inc.; Gina Geraci, Novartis Institutes for Biomedical Research Inc.; Linhong Yang, Novartis Institutes for Biomedical Research Inc.; Jianling Wang, Novartis Institutes for Biomedical Research Inc.; Upendra A. Argikar, Novartis Institutes for Biomedical Research Inc.
A novel in vitro approach for risk assessment of reactive metabolites in Drug Discovery
Richard A. Thompson, AstraZeneca R&D Molndal; Emre M. Isin, AstraZeneca R&D Molndal; Yan Li, AstraZeneca; Lars Weidolf, AstraZeneca R&D Molndal; Ian Wilson, AstraZeneca; Ken Page, AstraZeneca; Steve Swallow, AstraZeneca; Gerry Kenna, AstraZeneca
Bioactivation and Dehydrogenation of Naltrexone and Oxycodone in Human Liver Microsomes: Identification of the Reactive Quinone Methide Species
Bo Wen, Hoffmann-La Roche; Jiansheng Huang, Hoffmann-La Roche; David Moore, Hoffmann-La Roche Inc.
Effect on GSH and GSSG Levels in Rats Treated with Acetaminophen and Tamoxifen Using LC-MS/MS
Helen L. Shen, QPS, LLC; Lata Venkatarangan, QPS, LLC; Bruce Aungst, QPS, LLC; Zamas Lam, QPS, LLC
Intrauterine Origin of Caffeine-Induced High Susceptibility to Adult Metabolic Syndrome: Alleviated Glucocorticoid Inactivation Alters the Neuroendocrine Metabolic Programming of Fetal Rats
Dan Xu, Basic Medical School of Wuhan University, Wuhan 430071, China; Benjian Zhang, Basic Medical School of Wuhan University, Wuhan 430071, China; Jie Ping, Basic Medical School of Wuhan University, Wuhan 430071, China; Gai Liang, Basic Medical School of Wuhan University, Wuhan 430071, China; Fang Liu, Basic Medical School of Wuhan University, Wuhan 430071, China; Hao Kou, Basic Medical School of Wuhan University, Wuhan 430071, China; Xiao-jun Li, Basic Medical School of Wuhan University, Wuhan 430071, China; You-ying Lei, Basic Medical School of Wuhan University, Wuhan 430071, China; Hui Wang, Basic Medical School of Wuhan University, Wuhan 430071, China
Pyrrolizidine Alkaloids Induce Fetal Developmental Toxicities in Mice
Hao Kou, Basic Medical School of Wuhan University, Wuhan 430071, China; Jie Xiong, Basic Medical School of Wuhan University, Wuhan 430071, China; Zhen-guo Ma, Basic Medical School of Wuhan University, Wuhan 430071, China; Jiang Zheng, University of Washington; Yu Guo, Basic Medical School of Wuhan University, Wuhan 430071, China; Hui Wang, Basic Medical School of Wuhan University, Wuhan 430071, China
Risk Assessment for Idiosyncratic Hepatotoxicity of a BACE1 Inhibitor by Covalent Binding in Human S9 Fractions
Louis Leung, Pfizer Inc.; Zhuang Miao, Pfizer Inc.; Michael Brodney, Pfizer Inc.; Kevin Ogilvie, Pfizer Inc.; Klass Schildknegt, Pfizer Inc.; JianHua Liu, Pfizer Inc.; R. Scott Obach, Pfizer Inc.
THYROXINE (T4) CATABOLISM IN HUMAN AND RAT HEPATOCYTES INCREASES FOLLOWING EXPOSURE TO PROTOTYPICAL HEPATIC ENZYME INDUCERS
Vicki M. Richardson, USEPA and UNC at Chapel Hill; Yusupha M. Sey, USEPA; Michael J. DeVito, NIEHS/NTP
Zomepirac Acyl Glucuronide Migration
Rongfang Fran Xu, Johnson & Johnson Pharmaceutical Research and Development; Heang Keang Lim, Johnson & Johnson Pharmaceutical Research and Development; Michael McMillian, Johnson & Johnson Pharmaceutical Research and Development, LLC.