Clearance Prediction

Accurate prediction of hepatic clearance for low-clearance compounds using micropatterned hepatocyte-stromal cell co-cultures (HepatoPac®)
Tom S. Chan, Boehringer Ingelheim Pharmaceuticals Inc.; Salman Khetani, Hepregen Corporation; Amanda Moore, Hepregen Corporation; Hongbin Yu, Boehringer Ingelheim Pharmaceuticals Inc.
An In vivo-In vitro Correlation of Hepatic Clearance for Metabolism by Non-CYP with Custom Pooled Hepatocytes
Takafumi Akabane, Astellas Pharma Inc.; Nicolas Gerst, Astellas Rsch Inst of America; Jeffrey N. Masters, Astellas Rsch Inst of America; Kouichi Tamura, Astellas Rsch Inst of America
An Integrated Approach For Validating and Delivering In Silico Human Liver Microsome Clearance Models To Discovery Scientists
Ignacio Aliagas, Genentech Inc.; Alberto Gobbi, Genentech Inc.; Cyrus Khojasteh, Genentech Inc.; Jane Kenny, Genentech Inc.; Man Ling Lee, Genentech Inc.; Daniel Ortwine, Genentech Inc.
Be Careful What You Ask for: Challenges of Predicting Human Clearance for a Low Metabolic Turnover Compound, ELND006
Kevin Quinn, Elan Pharmaceuticals; David Nakamura, Elan Pharmaceuticals; Heather Zhang, Elan Pharmaceuticals; Shawn Gauby, Elan Pharmaceuticals; Colin Lorentzen, Elan Pharmaceuticals; Erich Goldbach, Elan Pharmaceuticals; Amanda Moore, Hepregen Corporation; Salman Khetani, Hepregen Corporation; Earvin Liang, Elan Pharmaceuticals; John-Michael Sauer, Elan Pharmaceuticals; George Tonn, Elan Pharmaceuticals
Prediction of PK parameters of human using human chimeric mice
Seigo Sanoh, Hiroshima University; Aya Horiguchi, Hiroshima University; Kazumi Sugihara, Hiroshima International University; Chise Tateno, PhoenixBio Co., Ltd.; Toru Horie, De Three Reseach Laboratories; Shigeyuki Kitamura, Nihon Pharmaceutical University; Shigeru Ohta, Hiroshima University
UTILIZATION OF CHIMERIC MICE WITH HUMANIZED LIVER AS A USEFUL MODEL FOR PREDICTING HUMAN PHARMACOKINETICS (PK) OF A DRUG CANDIDATE WITH MAJOR ALDEHYDE OXIDASE (AO) METABOLISM
Maria D. Bacolod, Lundbeck Research USA, Inc.; Kimloan Nguyen, Lundbeck Research USA, Inc.; Zack Zou, Lundbeck Research USA, Inc.; Guiying Li, Lundbeck Research USA, Inc.; Hao Zhou, Lundbeck Research USA, Inc.; Dario Doller, Lundbeck Research USA, Inc.; Gamini Chandrasena, Lundbeck Research USA, Inc.