Enzyme Induction

ASSESSING MODELING AND SIMULATION TOOLS AND METHODS FOR PREDICTING INDUCTION-BASED DRUG-DRUG INTERACTIONS: A COLLABORATIVE EFFORT BETWEEN ACADEMIC, GOVERNMENT REGULATORY, AND PHARMACEUTICAL SCIENTISTS FROM THE IQ CONSORTIUM (IQC)
Heidi Einolf, Novartis Institutes for BioMedical Research Inc.; Liangfu Chen, GlaxoSmithKline; Odette A. Fahmi, Pfizer; Christopher R. Gibson, Merck Research Laboratories; R. Scott Obach, Pfizer Global Research & Development; Mohamad Shebley, Abbott Laboratories; Michael Sinz, Bristol-Myers Squibb Co; Jose Silva, Johnson & Johnson Pharmaceutical Research and Development, LLC.; Jashvant D. Unadkat, University of Washington; Lei Zhang, U.S. Food and Drug Administration; Ping Zhao, CDER, FDA
Acrylamide Induction of CYP2E1 in the Rabbit Liver
Mine Nuyan Akkeçi, Middle East Technical University; Sevki Arslan, Middle East Technical University; Çigdem Kalin, Middle East Technical University; Emel Arinç, Middle East Technical University
CYP1A and CYP3A Induction in Cryopreserved Cynomolgus Monkey Hepatocytes Pooled from Multiple Donors
Utkarsh Doshi, In Vitro ADMET Laboratories LLC; Qian Yang, In Vitro ADMET Laboratories LLC; Nicole Li, In Vitro ADMET Laboratories LLC; Albert Li, In Vitro ADMET Laboratories LLC; JeanClare Seagrave, Lovelace Respiratory Research Institute
DPX2 Cells as a Model System for Detecting PXR-Mediated Induction of CYP3A Enzymes by Therapeutic Agents; Utility for DDI Predictions
Odette A. Fahmi, Pfizer; Judy Raucy, Puracyp, Inc; Elsa Ponce, Puracyp, Inc; Jerome M. Lasker, Puracyp, Inc
Development of Ex-vivo Drug Metabolizing Enzyme Assays in the Domestic Shorthair Cat (Felis catus)
Shangara S. Dehal, BD Biosciences Discovery Labware; Thuy Ho, BD Biosciences Discovery Labware; Andrew P. Blanchard, BD Biosciences Discovery Labware; George Zhang, BD Biosciences Discovery Labware; Nathalie Boily, BD Biosciences Discovery Labware; David M. Stresser, BD Biosciences Discovery Labware
Effects of pregnancy-specific somatotropins on cytochrome P450 (CYP) expression in human hepatocytes
Hye Jin Chung, College of Pharmacy, University of Illinois at Chicago; Liam Fischer, College of Pharmacy, University of Illinois at Chicago; Hyunyoung Jeong, University of Illinois at Chicago
In Vitro Evaluation of Novel PPAR-Sparing Insulin Sensitizers and Their Pharmacologically Active Hydroxy Metabolites as Inducers of CYP450 Expression in Cultured Human Hepatocytes
Wade J. Adams, Metabolic Solutions Development Company; Immaculate Amunon, XenoTech, LLC; Jerry R. Colca, Metabolic Solutions Development Company; Jason N. Neat, Metabolic Solutions Development Company
Profiling of NCEs in a PXR Reporter Cell Line and Human Hepatocytes to Adopt a Best-Practice Approach for Identifying CYP3A Inducers in Drug Discovery
Kevin J. Coe, Janssen Pharmaceutical Companies of Johnson & Johnson; Judith Skaptason, Janssen Pharmaceutical Companies of Johnson & Johnson; Robyn Buerger, Janssen Pharmaceutical Companies of Johnson & Johnson; Chrissa Ferguson, Janssen Pharmaceutical Companies of Johnson & Johnson; Zhengyin Yan, Janssen Pharmaceutical Companies of Johnson & Johnson; Gary Caldwell, Janssen Pharmaceutical Companies of Johnson & Johnson; Tatiana Koudriakova, Janssen Pharmaceutical Companies of Johnson & Johnson