17th North American Regional ISSX Meeting (October 16 - 20, 2011): Gene Expression and Regulation

P157

A Standardized Decoction Of Nigella sativa Seeds, Hemidesmus indicus Roots And Smilax glabra Rhizomes Induces Apoptosis In Human Hepatocellular Carcinoma (HepG2) Cells
Sameera R. Samarakoon, Institute of Biochemistry, Molecular Biology, and Biotechnology,University of Colombo; Ira M. Thabrew, Institute of Biochemistry, Molecular Biology, and Biotechnology, University of Colombo; Prasanna B. Galhena, Faculty of Medicine, University of Kelaniya; Kamani Tennekoon, Institute of Biochemistry, Molecular Biology, and Biotechnology, University of Colombo

P158

Analysis of the Endoplasmic Reticulum Stress Response in Progressive Human Non-Alcoholic Fatty Liver Disease
April D. Lake, University of Arizona; Petr Novak, University of Arizona and Institute of Plant Molecular Biology in the Czech Republic; Rhiannon N. Hardwick, University of Arizona; Nathan J. Cherrington, University of Arizona

P159

Collagen Antibody Induced Arthritis (CAIA) In Mice and Primary Mouse Hepatocyte Culture as Models to Study P450 Suppression: In Vivo/In Vitro Similarities and Differences
Leslie J. Dickmann, Amgen Inc.; Sonal K. Patel, Amgen Inc.; Helen McBride, Amgen Inc.; Kent Miner, Amgen Inc.; Larry C. Wienkers, Amgen Inc.; J. Greg Slatter, Amgen Inc.

P160

Constitutive androstane receptor transactivates human ABCG2 in hepatocytes through a novel cis-element in the distal promoter
Kouichi Yoshinari, Tohoku University; Satoshi Benoki, Tohoku University; Tsubasa Chikada, Tohoku University; Jun Imai, Tohoku University; Yasushi Yamazoe, Tohoku University

P162

Global Gene Expression Changes Induced In Primary Human Hepatocytes By Thiazolidinediones Upon Repeat Dosing of HepatoPac™ Cultures
Michael McVay, Hepregen Corporation; Salman Khetani, Hepregen Corporation

P163

Identification and Characterization of ABCG2 Enhancer Regions
Rachel J. Eclov, University of California of San Francisco; Nadav Ahituv, University of California of San Francisco; Deanna L. Kroetz, University of California of San Francisco

P164

In Vitro Effects of Cytokines on Cytochrome P450 Expression in Human Hepatocyte Culture
Leslie J. Dickmann, Amgen Inc.; Sonal K. Patel, Amgen Inc.; Larry C. Wienkers, Amgen Inc.; J. Greg Slatter, Amgen Inc.

P165

Influence of inflammatory processes on ADME gene expression in human liver and hepatocytes
Marcus Klein, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Benjamin A. Kandel, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Kathrin Klein, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Maria Thomas, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Wolfgang E. Thasler, LM University Munich, Hospital Grosshardern; Matthias Schwab, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology

P166

Investigating Receptor Crosstalk and ADME Gene Expression Using a High-Throughput RT-qPCR Method in Human Hepatocytes and HepaRG Cells
Joshua G. DeKeyser, Amgen Inc.; Michael Hayashi, Amgen Inc.; Magang Shou, Amgen Inc.

P167

Lentiviral knock down of the nuclear receptors CAR and PXR in human hepatocytes
Benjamin A. Kandel, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Jessica K. Rieger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Maria Thomas, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Nina Hofmann, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Daniel Knobeloch, Charité Universitätsmedizin Berlin; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology

P168

MicroRNAs in Posttranscriptional Regulation of Drug Metabolism and Disposition
Ai-Ming Yu, University at Buffalo, SUNY

P169

Molecular regulation of aldehyde dehydrogenase 1a1 by electrophiles: Role of AP-1 transcription factors
Ngome L. Makia, U. Louisville School of Medicine; Keith Cameron Falkner, University of Louisville; Daniel J. Conklin, U. Louisville School of Medicine; Russell A. Prough, University of Louisville School of Medicine

P170

Temporal changes in CYP3A4 mRNA and activity following treatment of cultured human hepatocytes with interleukin-6 (IL-6): Implications for study design and endpoint selection
Michelle McBride, XenoTech, LLC; Jason Neat, XenoTech, LLC; David Buckley, XenoTech, LLC; Jennifer Simpson, XenoTech, LLC; Bradley Klaus, XenoTech, LLC; Janet Sawi, XenoTech, LLC; Paul Bolliger, XenoTech, LLC; Andrew Parkinson, XenoTech, LLC