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Hepatocytes

P177
A Novel Human Hepatocyte Culture Medium for the Maintenance of P450, Uptake Transporters, and Efflux Transporters
Albert P. Li, In Vitro ADMET Laboratories LLC; Qian Yang, In Vitro ADMET Laboratories LLC; Utkarsh Doshi, In Vitro ADMET Laboratories LLC
P178
A long term culture model for primary hepatocytes from Cynomolgus monkeys
Simon Aoyama, Hepregen Corporation; Sara Lambirth, Hepregen Corporation; Salman Khetani, Hepregen Corporation
P179
Assessment of Uptake Contributions of Hepatic Uptake Transporters
Yi-an Bi, Pfizer Inc.; Charles Rotter, Pfizer Inc.; Emi Kimoto, Pfizer Inc.; Kevin Whalen, Pfizer Inc.; Bo Feng, Pfizer Inc.; Manthena Varma, Pfizer Inc.; Ayman El-Kattan, Pfizer Inc.; Yurong Lai, Pfizer Inc.
P180
Comparison of Uptake Clearance of Rat and Human Hepatocytes
Yi-an Bi, Pfizer Inc.; Emi Kimoto, Pfizer Inc.; Kevin Whalen, Pfizer Inc.; Ayman EI-Kattan, Pfizer Inc.; Yurong Lai, Pfizer Inc.
P181
Comparison of different in vitro hepatic systems for evaluation of intrinsic clearance
Rongjun Zuo, BD Biosciences; Sweta Parikh, BD Biosciences; Charles L. Crespi, BD Biosciences; Chris Patten, BD Biosciences
P182
Cryo-preserved HepaRG™ Cells: An Alternative to Primary Human Hepatocytes for Drug-Drug Interaction and Safety Applications
Jonathan P. Jackson, Life Technologies; Manda Edwards, Life Technologies; Erica Deibert, Life Technologies; Stephen S. Ferguson, Life Technologies
P183
Evaluation of a 96-well plate induction assay: the impact of different extracellular matrix based growth substrates on induction potential of Cytochrome P450, UDP-DEPENDENT GLUCURONYL TRANSFERASE, transporter proteins with multiple endpoints
Rongjun Zuo, BD Biosciences; Haiyan Xia, BD Biosciences; Chris Patten, BD Biosciences
P184
Evidence for CYP2C9:CYP3A4 enzyme activity interactions in human hepatocytes through modulation of enzyme levels
Diane B. Ramsden, Boehringer Ingelheim; Tom S. Chan, Boehringer Ingelheim; Timothy S. Tracy, University of Kentucky
P185
Expression And Activity Levels Of Cytochrome P450 In 1-week Spheroid Culture Of Rat Hepatocyte On Nanopillar Sheets
Toshito Nakagawa, Chugai Pharmaceut Co Ltd; Atsuko Higashida, Chugai Pharmaceut Co Ltd; Kunihiro Ohta, Chugai Pharmaceut Co Ltd; Masaki Ishigai, Chugai Pharmaceut Co Ltd
P186
GigaMatrix Differentiates Stem/Progenitor Cells into Mature Functional Hepatocytes
Marsha Roach, GigaCyte, LLC; Richard Malavarca, GigaCyte, LLC; Shawn Hallowell, GigaCyte, LLC; Linyan He, GigaCyte, LLC; Lola Reid, University of North Carolina
P187
Hepatobiliary Disposition of Bilirubin and its Mono- and Di-glucuronide Metabolites in Sandwich-Cultured Rat Hepatocytes
Jin Kyung Lee, Qualyst Inc; Robert Hart, Qualyst Inc; Brouwer Kenneth, Qualyst Inc
P188
Long Term Storage Effects on the Metabolic Activity of Cryopreserved Primary Human and Rat Hepatocytes
Todd W. Stewart, Life Technologies; Christina K. Nolan, Life Technologies; Rafal P. Witek, Life Technologies; Brian J. Paszkiet, Life Technologies; Stephen S. Ferguson, Life Technologies; Cornelia M. Smith, Life Technologies
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