In Vitro Techniques

A Novel Cellular Model for Drug-induced Adipogenesis
Aarti Uzgare, In Vitro ADMET Laboratories LLC; Utkarsh Doshi, In Vitro ADMET Laboratories LLC; Albert Li, In Vitro ADMET Laboratories LLC
A robust method to identify compounds that undergo intracellular lysosomal sequestration
Faraz Kazmi, XenoTech, LLC; Ryan Funk, University of Kansas; Chad Pope, XenoTech, LLC; Maciej Czerwinski, XenoTech, LLC; David Buckley, XenoTech, LLC; Andrew Parkinson, XenoTech, LLC
An Effective Screening Approach to Assess the Impact of α-1 Acid Glycoprotein Binding on the Unbound Fraction of a Drug
Karin D. Brown, Array BioPharma Inc.; Gary P. Hingorani, Array BioPharma Inc.; Ronald B. Franklin, Array BioPharma Inc.
An Improved Approach to Characterize Unbound Drug Concentrations
David A. Erickson, Covance Labs Inc; Kari Landsverk, Covance Labs Inc; Nicole Engh, Covance Labs Inc; Kristen Cardinal, Covance Labs Inc; Michele Hamrick, Covance Labs Inc; Kristine Horabik, Covance Labs Inc; Jody Wanta, Covance Labs Inc; Richard Ridgewell, Covance Labs Inc
Approaches To Understanding The Impact Of Blood Partitioning In Drug Discovery
Tim J. Potter, Cyprotex Discovery; Clive Dilworth, Cyprotex Discovery; Sally Lee, Cyprotex Discovery; Hollie Adey, Cyprotex Discovery; Bernard P. Murray, Gilead Sciences, Inc.
CHARACTERIZATION OF A HUMAN HEPATOCELLUAR CARCINOMA CELL LINE ON MICRO-SPACE CELL CULTURE PLATE
Yoko Ejiri, Kuraray Co., Ltd.; Akane Yoshida, Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University; Masaya Hosoda, Kuraray Co., Ltd.; Kaoru Kobayashi, Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University; Kan Chiba, Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
Evaluating the potential for lysosomal trapping in immortalized human hepatocytes (Fa2N-4 cells)
Tiffini Hensley, XenoTech, LLC; Greg J. Loewen, XenoTech, LLC; Faraz Kazmi, XenoTech, LLC; Brian Ogilvie, XenoTech, LLC; David Buckley, XenoTech, LLC; Andrew Parkinson, XenoTech, LLC
Functional Evaluation of 3D-culture of Human Hepatocytes on Cell-able under Newly Optimized Condition
Shin Enosawa, National Center for Child Health and Development; Yuriko Takahashi, National Center for Child Health and Development; Tomoko Jomura, Transparent Inc.; Emiko Ozeki, Transparent Inc.; Takeshi Ikeya, Transparent Inc.
In Vitro Reactivity Assessment of Covalent Drugs Targeting Bruton's Tyrosine Kinase
Matthew Labenski, Avila Therapeutics; Prasoon Chaturvedi, Avila Therapeutics; Erica Evans, Avila Therapeutics; Hormoz Mazdiyazni, Avila Therapeutics; Michael Sheets, Avila Therapeutics; Sharon Aslanian, Avila Therapeutics; Mariana Nacht, Avila Therapeutics; Russell Petter, Avila Therapeutics; Juswinder Singh, Avila Therapeutics; William Westlin, Avila Therapeutics
Increase of Glucuronidation in Human Liver Microsomes by PLA2 Inhibition: Implications for Improved PK Predictions
Erin F. Mulrooney, Merck; Sebastien Gagné, Merck Frosst Canada & Co.; Cody van Dijk, Merck Frosst Canada & Co.; Julien Breault-Turcot, Merck Frosst Canada & Co.; Jean-François Lévesque, Merck Frosst Canada & Co.; Deborah A. Nicoll-Griffith, Merck & Co
Integrated Discrete Multiple Organ Co-culture (IdMOC) System for the Evaluation of Multiple Organ Drug Distribution, Drug Metabolism, and Organ Specific Drug Toxicity
Albert P. Li, In Vitro ADMET Laboratories LLC; Utkarsh Doshi, In Vitro ADMET Laboratories LLC; Aarti Uzgare, In Vitro ADMET Laboratories LLC; Hariharan Saminathan, In Vitro ADMET Laboratories LLC; Qian Yang, In Vitro ADMET Laboratories LLC