17th North American Regional ISSX Meeting (October 16

P271

A functional SNP in Aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple Cytochrome's P450 (CYPs)
Amarjit S. Chaudhry, St. Jude Children's Research Hospital; Ranjit K. Thirumaran, St. Jude Children's Research Hospital; Xia Yang, Rosetta Inpharmatics; Frederick Peter Guengerich, Vanderbilt University School of Medicine; Stephen C. Strom, University of Pittsburgh; Erin G. Schuetz, St. Jude Children's Research Hospital

P272

Extensive Pathway Oriented Candidate Gene Approach Allows Identification of Factors Influencing CYP3A4 Expression and Function
Kathrin Klein, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Maria Thomas, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Stefan Winter, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Thomas Weiss, University of Regensburg; Matthias Schwab, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology

P273

Functional assessment of CNV's in human liver
Roman Tremmel, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Kathrin Klein, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Stefan Winter, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Matthias Schwab, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology

P274

Influence of MDR1 and NFKBIA polymorphisms on Cyclosporin A concentrations in Chinese renal transplant recipients
Huang Min, Sun Yat-sen University; Zhang Yu, Sun Yat-sen University; Li Jiali, Sun Yat-sen University; Wang Xueding, Sun Yat-sen University; Wang Changxi, Sun Yat-sen University

P275

Pharmacogenomics Of Thiopurine Response: Use of a Lymphoblastoid Cell Line (LCL) Model System To Identify SNPs Associated With Clinical Response And Functional Validation Of Candidate Genes
Alice Matimba, Mayo Clinic; Fang Li, Mayo Clinic; Alina Livshits, Mayo Clinic; Cher S. Cartwright, University of Sheffield; Brooke Fridley, Mayo Clinic; Gregory Jenkins, Mayo Clinic; Anthony Batzler, Mayo Clinic; Richard Weinshilboum, Mayo Clinic; Lynne Lennard, University of Sheffield

P276

Prevalence and Functional Characterization of Non-coding Polymorphisms in the Cytochrome b₅ / NADH Cytochrome b₅ Reductase Detoxification Pathway
Kristina L. Blanke, University of Wisconsin Madison; James Sacco, University of Wisconsin Madison; Robert Millikan, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Lauren Trepanier, University of Wisconsin Madison

P277

Regulatory polymorphism in promoter region of CYP2C9 affects mRNA expression in human livers
Danxin Wang, The Ohio State University

Pharmacogenetics