17th North American Regional ISSX Meeting (October 16 - 20, 2011): Pharmacokinetics and Pharmacodynamics

P278

Bioactivity in vitro and Pharmacokinetics in vivo of hypoglycemic protein E2HSA
Guifang Dou, Beijing Institute of Transfusion Medicine; Zhiyun Meng, Beijing Institute of Transfusion Medicine

P279

CYP2B6 Genetic Polymorphism and its Impact on Efavirenz Plasma Levels in HIV/AIDS Out-Patients of African Origin
Benjamin U. Ebeshi, Niger Delta University; Margaret Oluka, University of Nairobi; Oluseye O. Bolaji, Obafemi Awolowo University; Anastasia N. Guantai, University of Nairobi; Collen M. Masimirembwa, African Institute of Biomedical Science & Technology

P280

Comparison of Dried Blood Spot vs. Plasma Sampling Utilizing the Culex-L Automated Blood Collection System for Canine Pharmacokinetic Studies
Brad Gien, BASi-Evansville; L. David Hopper, BASi-Evansville; Vance Cooper, BASi; Tyler DeGraw, BASi-WL; Lori Payne, BASi; Candace Rohde Johnson, BASi-WL; S. Calugaru, BASi; A.J. Hoehn, BASi-Evansville; P. Downing, BASi-Evansville; R. Sun, BASi-WL

P281

Different Response of Cilostazol and its Metabolites, 3,4-dehydrocilostazol and 4-transhydroxy cilostazol, in Relation to Platelet Accumulation
Boram Kang, Inje University College of Medicine; Su Jeong Lim, Inje University College of Medicine; Yeong-Lim Choi, Inje University College of Medicine; Min Hye Kim, Inje University College of Medicine; Ho-Jung Shin, Inje University College of Medicine; Ji Eun Seo, Inje University College of Medicine; Yun Mi Lee, Inje University College of Medicine; Jae-Gook Shin, Inje University College of Medicine; Im-Sook Song, Inje University College of Medicine

P282

Effect of Aripiprazole in an Animal Model of Alcohol Addiction and its Pharmacokinetics and Dopamine D2 Receptor Occupancy in Rats
Gopinadh Bhyrapuneni, Suven Life Sciences Ltd; Ramanatha Saralaya, Suven Life Sciences Ltd; Pradeep Jayarajan, Suven Life Sciences Ltd; Vishwottam Kandikere, Suven Life Sciences Ltd; Nageswararao Muddana, Suven Life Sciences Ltd; Devender Reddy Ajjala, Suven Life Sciences Ltd; Ramakrishna Suraneni, Suven Life Sciences Ltd; Ramakrishna Nirogi, Suven Life Sciences Ltd

P283

Effect of Generic Warfarin Sodium Formulation on Its Clinical Steady State Concentrations
Zhou Limin, The Chinese University of Hong Kong; Wo Siu Kwan, The Chinese University of Hong Kong; You Hoi Sze, The Chinese University of Hong Kong; Bolger MB, Simulations Plus Inc.; Zuo Zhong, The Chinese University of Hong Kong

P284

Gender Differences in Pharmacokinetics of Fluoxetine in Newborn Lambs up to 1 Month of Age
Timothy Chow, University of British Columbia; Tuan-Anh Nguyen, University of British Columbia; Dan Rurak, University of British Columbia; Wayne Riggs, University of British Columbia

P285

Grouping Plasma Pharmacokinetic Profiles Using Kohonen Self-organizing Maps
Jason L. Boyd, Simulations Plus Inc.; Robert Fraczkiewicz, Simulations Plus Inc.; Grazyna Fraczkiewicz, Simulations Plus Inc.; Robert D. Clark, Simulations Plus Inc.; Walter S. Woltosz, Simulations Plus Inc.

P286

Impact of CYP2D6 and MAO-A in Indolealkylamine Metabolism, Pharmacokinetics and Dynamics
Ai-Ming Yu, University at Buffalo, SUNY

P287

Pharmacokinetic and Pharmacodynamic Implications of Disease-associated Changes in Plasma Protein Binding
Rahul Deshmukh, Abbott; Neil Wishart, Abbott; Jeffrey Voss, Abbott; Robert Carr, Abbott; Michael Firedman, Abbott; Deborah Hyland, Abbott; Anwar Murtuza, Abbott; Heather Blanchette, Cubsit Pharmaceuticals

P288

Pharmacokinetic effect of voriconazole on cyclosporine in the treatment of aspergillosis after renal transplantation
Choi Da-Hyeon, Inje University College of Medicine

P290

Pharmacokinetics In Rats: Small Blood Volume Sampling And LC Analysis
M.A.M Wenker, NOTOX B.V.; M. Eman, NOTOX B.V.; T. Noij, NOTOX B.V.; H.H. Emmen, NOTOX B.V.

P291

Pharmacokinetics and brain permeability of 3,5,4'-trimethoxy-trans-stilbene (TMS)
Satish Sharan, Temple University; Swati Nagar, Temple University School of Pharmacy

P292

Pharmacokinetics of 40kDa PEG in Rodents Using High-Field NMR Spectroscopy
Purnima Khandelwal, Bristol-Myers Squibb; Lisa Zhang, Bristol-Myers Squibb; Anjaneya Chimalakonda, Bristol-Myers Squibb; Janet Caceres-Cortes, Bristol-Myers Squibb; Christine Huang, Bristol-Myers Squibb; Punit Marathe, Bristol-Myers Squibb; Michael D. Reily, Bristol-Myers Squibb

P293

Preclinical Disposition and Pharmacokinetics-Pharmacodynamic Modeling of Tumor Growth Inhibition in Xenograft Mouse Models with a MEK Inhibitor, GDC-0973
Edna F. Choo, Genentech Inc.; Marcia Belvin, Genentech Inc.; Jason Boggs, Genentech Inc.; Alan Deng, Genentech Inc.; Klaus Hoeflich, Genentech Inc.; Justin Ly, Genentech Inc.; Mark Merchant, Genentech Inc.; Christine Orr, Genentech Inc.; Kirk Robarge, Genentech Inc.; Harvey Wong, Genentech Inc.

P294

Predictability of Glutathione Transferase Zeta 1 Haplotype on Kinetics of Dichloroacetate in Human Trials
Peter W. Stacpoole, University of Florida College of Medicine; Erin M. Dunbar, University of Florida College of Medicine; Albert L. Shroads, University of Florida College of Medicine; Bonnie S. Coats, University of Florida College of Medicine; Taimour Langaee, University of Florida

P295

Rapid PK: An Efficient In Vivo Preclinical Pharmacokinetic Approach To Support Drug Discovery
Chun Li, Genomics Institute of the Novartis Research Foundation; Bo Liu, Genomics Institute of the Novartis Research Foundation; Jonathan Chang, Genomics Institute of the Novartis Research Foundation; Todd Groessl, Genomics Institute of the Novartis Research Foundation; Liang Wang, Genomics Institute of the Novartis Research Foundation; YouQun He, Genomics Institute of the Novartis Research Foundation; Matt Zimmerman, Genomics Institute of the Novartis Research Foundation; John Isbell, Genomics Institute of the Novartis Research Foundation; Tove Tuntland, Genomics Institute of the Novartis Research Foundation

P296

Stereoselective pharmacokinetics of (�)-praeruptorin A in rats
Yuelin Song, Institute of Chinese Medical Sciences; Ruina Zhou, Institute of Chinese Medical Sciences; Ru Yan, Institute of Chinese Medical Sciences; Yitao Wang, Institute of Chinese Medical Sciences