Transporters

A Time-Course Study on the Effects of Interleukin-6 on Gene Expression of P450 Isoforms, Uptake Transporters, and Efflux Transporters in Human Hepatocytes
Qian Yang, In Vitro ADMET Laboratories LLC; Utkarsh Doshi, In Vitro ADMET Laboratories LLC; Nicole Li, In Vitro ADMET Laboratories LLC; Albert Li, In Vitro ADMET Laboratories LLC
A novel in vitro mrp2 assay to predict in vivo biliary excretion
Federico Colombo, Boehringer Ingelheim Canada Ltd; Catherine Armstrong, Boehringer Ingelheim Canada Ltd; Jianmin Duan, Boehringer Ingelheim Canada Ltd; Nathalie Rioux, Boehringer Ingelheim Canada Ltd
Application of Receiver Operating Characteristics to Assess Digoxin Drug Interaction Potential
Caroline A. Lee, Pfizer Inc.; Joseph Bentz, Drexel University; Michael O'Connor, Drexel University; Johan Palm, AstraZeneca; Harma Ellens, GlaxoSmithKline; Krisztina Heredi-Szabo, SOLVO Biotechnology; Dallas Bednarczyk, Novartis; Mitchell Taub, Boehringer-Ingelheim Pharmaceuticals, Inc.; Elke S. Perloff, BD Biosciences; Christoph Funk, Hoffmann-La Roche Ltd; Praveen Balimane, Bristol-Myers Squibb; Laurent Salphati, Genentech Inc.; Ailan Guo, Hoffmann-La Roche Inc.; Lalitha Podila, Boehringer Ingelheim Pharmaceuticals, Inc.; Imad Hanna, Novartis Institutes for BioMedical Research Inc.; Cindy Xia, Millennium Pharmaceuticals, Inc.; Libin Li, Absorption Systems LP; Guangqing Xiao, Biogen Inc; Heleen M. Wortelboer, TNO Quality of Life; Dietmar Weitz, Sanofi-Aventis; Youngeen A. Pak, Eli Lilly and Company; Eric Reyner, Pfizer Global Research & Development; Jesse Taur, Eisai; Xiaoyan Chu, Merck & Co Inc-Merck Rsch Lab; Ulrike Gradhand, Merck KGaA; Mark Warren, Optivia; Ganesh Rajaraman, Life Technologies - CellzDirect; Lei Zhang, U.S. Food and Drug Administration
Automated 96-Well Assay for the Assessment of Passive Permeability and P-gp Efflux During CNS Drug Discovery
Colin Lorenzten, Elan Pharmaceuticals; Shawn Gauby, Elan Pharmaceuticals; David Nakamura, Elan Pharmaceuticals; Heather Zhang, Elan Pharmaceuticals; Erich Goldbach, Elan Pharmaceuticals; Shaila Hoque, Elan Pharmaceuticals; Bhushan Samant, Elan Pharmaceuticals; Pamela Santiago, Elan Pharmaceuticals; Patrick Rudewicz, Elan Pharmaceuticals; John-Michael Sauer, Elan Pharmaceuticals; George Tonn, Elan Pharmaceuticals; Kevin Quinn, Elan Pharmaceuticals
Biliary Excretion and Pharmacokinetics of ABCG2 Substrates in Abcg2 Knockout Rats
Liyue Huang, Amgen Inc.; Xuhai Be, Amgen Inc.; Adria Colletti, Amgen Inc.; John Roberts, Amgen Inc.; Meghan Langley, Amgen Inc.; Min-Hwa J. Lin, Amgen Inc.; Zhiyang Zhao, Amgen Inc.; Bradley K. Wong, Amgen Inc.; Lixia Jin, Amgen Inc.
Characterization of ABC Transporters and SLC Transporters in Sandwich Cultured Human Cryopreserved Hepatocytes
Na Li, BD Biosciences; Rongjun Zuo, BD Biosciences; Kirsten Cooper, BD Biosciences; Peter Petrov, BD Biosciences; Joanne Bourgea, BD Biosciences; Charles Crespi, BD Biosciences; Christopher J. Patten, BD Biosciences
Characterization of Bcrp Knock-out Rat Model Using Gene Expression Analysis
Eskouhie H. Tchaparian, Amgen Inc.; Adria Colletti, Amgen Inc.; John Roberts, Amgen Inc.; Lixia Jin, Amgen Inc.
Comparison of Digoxin Efflux Inhibition in Caco-2 and MDR1-LLC-PK1 Cell Monolayers
Elke S. Perloff, BD GentestSM Contract Research Services; Andrew K Mason, BD GentestSM Contract Research Services; Sudarshan Kapadnis, BD GentestSM Contract Research Services; Wendy Khun, BD GentestSM Contract Research Services; Lisa G Fox, BD GentestSM Contract Research Services; David M. Stresser, BD GentestSM Contract Research Services
Creation and Characterization of ATP-Binding-Cassette Transporter Knockout Rat Models
Iara D. Carbery, Sigma-Aldrich; Lara Little, Sigma-Aldrich; Edward Weinstein, Sigma-Aldrich; Xiaoxia Cui, Sigma-Aldrich
Creation and assessment of adenovirus-mediated drug transporter model expression system for the prediction of pharmacokinetic profiles in humans
Daisuke Sugiyama, The University of Western Ontario; Wendy A. Teft, The University of Western Ontario; Mike J. Knauer, The University of Western Ontario; Marianne K. DeGorter, The University of Western Ontario; Rommel G. Tirona, The University of Western Ontario; Richard B. Kim, The University of Western Ontario
Determination of OATP Mediated Drug-Drug Interaction Potential in Pooled Cryopreserved Human Hepatocytes
Leena Laitinen, Vertex Pharmaceuticals, Inc.; Pamela McCarthy, Vertex Pharmaceuticals, Inc.; Brian Boucher, Vertex Pharmaceuticals, Inc.; Niresh Hariparsad, Vertex Pharmaceuticals, Inc.
Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Inside-out Vesicle Uptake Assay
Na Li, BD Biosciences; Sweta N. Parikh, BD Biosciences; Deqing Xiao, BD Biosciences; David Stresser, BD Biosciences; Charles L. Crespi, BD Biosciences; Christopher J. Patten, BD Biosciences
Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cells
Mitchell E. Taub, Boehringer Ingelheim Pharmaceuticals, Inc.; Kirsten Mease, Boehringer Ingelheim Pharmaceuticals, Inc.; Rucha S. Sane, Boehringer Ingelheim Pharmaceuticals, Inc.; Cory A. Watson, GlaxoSmithKline; Liangfu Chen, GlaxoSmithKline; Harma Ellens, GlaxoSmithKline; Brad Hirakawa, Pfizer Global Research & Development; Eric L. Reyner, Pfizer Global Research & Development; Márton Jani, SOLVO Biotechnology; Caroline A. Lee, Independent
ESTABLISHMENT OF STABLY TRANSFECTED CELL LINES EXPRESSING TRANSPORTERS KEY TO DRUG DISPOSITION
Gang Luo, Covance Laboratories Inc.; Kristen Cardinal, Covance Laboratories Inc.; Manuela Deavila, Covance Laboratories Inc.; Michele Hamrick, Covance Laboratories Inc.; Kristine Horabik, Covance Laboratories Inc.; Jeffrey Zuvon, Covance Laboratories Inc.; Liberty Liuperez, Covance Laboratories Inc.; Richard Ridgewell, Covance Laboratories Inc.
EXPRESSION OF ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATP) 1B1 AND 1B3 IN OVARIAN CANCER CELLS: RELEVANCE FOR PACLITAXEL TRANSPORT
Walter Jaeger, University of Vienna; Martin Svoboda, Medical University of Vienna; Katrin Wlcek, University of Vienna; Barbara Taferner, University of Vienna; Steffen Hering, University of Vienna; Bruno Stieger, University Hospital; Theresia Thalhammer, Medical University of Vienna
Effects of Antiretroviral Protease Inhibitors, Lopinavir and Ritonavir, on the Hepatobiliary Disposition of Bile Acids in Sandwich-Cultured Rat Hepatocytes
LaToya M. Griffin, University of North Carolina at Chapel Hill Eshelman School of Pharmacy; Kim L.R. Brouwer, University of North Carolina at Chapel Hill Eshelman School of Pharmacy
Effects of Protein Binding on Transporter Inhibitions
Qing Zhu, Millennium Pharmaceuticals, Inc.; Mingxiang Liao, Millennium Pharmaceuticals, Inc.; Bei-Ching Chuang, Millennium Pharmaceuticals, Inc.; Suresh K. Balani, Millennium Pharmaceuticals, Inc.; Cindy Xia, Millennium Pharmaceuticals, Inc.
Evaluation Of Uptake Transporters In Human Adult And Pediatric Hepatocytes
Michael Hayashi, Amgen Inc.; Andrew Hui, Amgen Inc.; Josh DeKeyser, Amgen Inc.; Steven Louie, Amgen Inc.; Magang Shou, Amgen Inc.; Lilly Xu, Amgen Inc.
Evaluation of P-glycoprotein expression in Pain Relevant Tissues Across Species for Understanding Translation of Efflux from Preclinical Species to Human
Renu S. Dhanikula, AstraZeneca R&D Montreal; Cyrla Hoffert, AstraZeneca R&D Montreal; Rebecca Grant, AstraZeneca R&D Montreal; Denis Projean, AstraZeneca R&D Montreal; Dajan O'Donnell, AstraZeneca R&D Montreal; Marie Roumi, AstraZeneca R&D Montreal
Evaluation of Transporter-Mediated Herb-Drug Interaction Potential of Berberine, Saikosaponin, and Glycyrrhizin
Da-Hyeon Choi, Inje University College of Medicine; Ho-Jung Shin, Inje University College of Medicine; Min Hye Kim, Inje University College of Medicine; Su Jeong Lim, Inje University College of Medicine; Boram Kang, Inje University College of Medicine; Jae-Gook Shin, Inje University College of Medicine; Im-Sook Song, Inje University College of Medicine
Functional Analysis of Pharmacogenetic Variants of Human Organic Cation/Carnitine Transporter 2 (hOCTN2) Identified in Singaporean Populations
Dorothy Su Lin Toh, University of Sydney; Michael Murray, University of Sydney; Tan Kuan Pern, Agency for Science, Technology and Research; Edmund Lee, National University of Singapore; Fanfan Zhou, University of Sydney
Human Organic Transporter 1(hOAT1) Affected the Renal Tubular Secretion of Antofloxacin
Kehua Shao, Institute of Clinical Pharmaclogy, Peking University; Minji Wei, Institute of Clinical Pharmaclogy, Peking University; Xiuli Zhao, Base for Clinical Trial, Tongren Hospital, Capital Medical University; Chao Jia, Base for Clinical Trial, Tongren Hospital, Capital Medical University
IDENTIFICATION OF A NOVEL FUNCTION OF SNBT1 AS A SODIUM-DEPENDENT URATE TRANSPORTER
Chihiro Nishijima, Nagoya City University; Katsuhisa Inoue, Nagoya City University; Kinya Ohta, Nagoya City University; Hiroaki Yuasa, Nagoya City University
INVOLVEMENT OF SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER-LIKE ACTIVITY IN NICOTINATE UPTAKE BY BRUSH BORDER MEMBRANE VESICLES FROM THE RAT SMALL INTESTINE
Hiroaki Yuasa, Nagoya City University; Masahiko Ohkubo, Nagoya City University; Kinya Ohta, Nagoya City University; Katsuhisa Inoue, Nagoya City University
In vitro characterization of transporters mediating hepatic uptake and biliary excretion of AMG009 in rats
Eskouhie H. Tchaparian, Amgen Inc.; Guifen Xu, Amgen Inc.; Yun Ling, Amgen Inc.; Tom Huang, Amgen Inc.; Mark P Grillo, Amgen Inc.; Lixia Jin, Amgen Inc.
Interaction of Milk with the Intestinal PEPT1-mediated Absorption of Oseltamivir in Rats and Humans
Kaori Morimoto, Takasaki University of Health and Welfare; Kozue Kishimura, Takasaki University of Health and Welfare; Megumi Tosaka, Takasaki University of Health and Welfare; Hideaki Asamizu, Takasaki University of Health and Welfare; Takaaki Nagami, Takasaki University of Health and Welfare; Nao Kodama, Takasaki University of Health and Welfare; Takashi Kano, Takasaki University of Health and Welfare; Ikumi Tamai, Kanazawa University; Takuo Ogihara, Takasaki University of Health and Welfare
Interaction of penciclovir with renal drug transporters
Adrienne Natrillo, Novartis Institutes for BioMedical Research Inc.; Arpine Vapurcuyan, Novartis Institutes for BioMedical Research Inc.; Yaofeng Cheng, Novartis Institutes for BioMedical Research Inc.; Ryan Pelis, Novartis Institutes for BioMedical Research Inc.
Interactions of FTY720 and FTY720-P with ATP-binding Cassette Transporters
Joy Wang, Massachusetts College of Pharmacy and Health Science; Eric Sands, BiogenIdec; Cheryl Black, BiogenIdec; David Williams, Massachusetts College of Pharmacy and Health Science; Monica Chuong, Massachusetts College of Pharmacy and Health Science; Eman Atef, Massachusetts College of Pharmacy and Health Science; Barbara LeDuc, Massachusetts College of Pharmacy and Health Science; Lawrence Gan, BiogenIdec; Guangqing Xiao, BiogenIdec
Interactions of Selected Antivirals with Human Organic Anion Transporter 1 In Vitro and Potential Influence of Drug Competitors
Jana Mandikova, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove; Zbynek Novy, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove; Marie Volkova, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove; Petr Pavek, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove; Frantisek Trejtnar, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove
Investigating the Role of UGT1A1, MRP2 and OATP1B1 in Drug Induced Liver Toxicity
Emile G. Plise, Genentech Inc.; Gillian Smelick, Genentech Inc.; Jonathan Cheong, Genentech Inc.; Jae H. Chang, Genentech Inc.
Involvement of P-glycoprotein in the Brain Distribution of Blonanserin
Tomoko Inoue, Dainippon Sumitomo Pharma Co., Ltd.; Masaaki Tagawa, Dainippon Sumitomo Pharma Co., Ltd.; Kenichi Osada, St. Marianna University School of Medicine; Yuriko Ogawa, St. Marianna University School of Medicine; Toshihisa Haga, St. Marianna University School of Medicine; Yoshihisa Sogame, Dainippon Sumitomo Pharma Co., Ltd.; Takashi Katsumata, Dainippon Sumitomo Pharma Co., Ltd.; Noboru Yamaguchi, St. Marianna University School of Medicine; Masashi Yabuki, Dainippon Sumitomo Pharma Co., Ltd.
Loxapine P-glycoprotein interactions in vitro
Andrea Reed, Alexza Pharmaceuticals Inc; Elke Perloff, BD Sioscis; Keith Huie, Alexza Pharmaceuticals Inc; Lori H. Takahashi, Alexza Pharmaceuticals Inc; James Cassella, Alexza Pharmaceuticals Inc
MOLECULAR IDENTIFICATION OF A NOVEL PROSTAGLANDIN E2 TRANSPORTER
Rika Hayashi, Nagoya City University; Katsuhisa Inoue, Nagoya City University; Kinya Ohta, Nagoya City University; Hiroaki Yuasa, Nagoya City University
Oatp1a/1b knockout mouse model useful for evaluating the importance of Oatp1a/1b transporters for hepatic uptake of SN-38, but not irinotecan
Dilek Iusuf, Netherlands Cancer Institute; Marion Ludwig, Netherlands Cancer Institute; Ahmed Elbatsh, Netherlands Cancer Institute; Anita van Esch, Netherlands Cancer Institute; Evita van de Steeg, Netherlands Cancer Institute; Els Wagenaar, Netherlands Cancer Institute; Olaf van Tellingen, Netherlands Cancer Institute; Alfred H. Schinkel, Netherlands Cancer Institute
PET Imaging of P-glycoprotein Inhibition at the Human Blood-Brain Barrier by Quinidine
Li Liu, University of Washington; Ann C. Collier, University of Washington; Jeanne M. Link, University of Washington; Karen B. Domino, University of Washington; David A. Mankoff, University of Washington; Janet F. Eary, University of Washington; Peng Hsiao, University of Washington; Anand K. Deo, University of Washington; Jashvant D. Unadkat, University of Washington
Primary Human Renal Proximal Tubule Cell Model for Study of Transepithelial Transport
Caitlin Brown, Celsis In Vitro Technologies; Yuko Kosaka, 3-V Biosciences; Marc J. Evanchik, 3-V Biosciences; Scott Heyward, Celsis In Vitro Technologies; Ji Young Lee, Celsis In Vitro Technologies
Rapid Screening of Human OATP1B1 and OATP1B3 Mediated Drug Interactions in Stably Transfected Human Embryonic Kidney HEK-293 Cell Lines Using Flow Cytometry and Fluorescence Microplate Methods
Steve Wright, Carson-Newman College; Ying Wang, Absorption Systems LP; Jibin Li, Absorption Systems LP; Albert Owen, Absorption Systems LP; Ismael Hidalgo, Absorption Systems LP
Regulation of Hepatic Uptake and Efflux Transporters in vitro
Gabrielle M. Hawksworth, University of Aberdeen; Muhammad Farooq, University of Aberdeen; Colin J. Henderson, Cancer Research UK Molecular Pharmacology Unit; Richard J. Weaver, Servier
The Impact of Grapefruit Juice on the Active Uptake of Drugs by Hepatic Transporters
Ron Scialis, Pfizer Inc.; Bo Feng, Pfizer Inc.; Emi Kimoto, Pfizer Inc.; Yurong Lai, Pfizer Inc.; Kevin Whalen, Pfizer Inc.; Ayman El-Kattan, Pfizer Inc.
Transporter-based in vitro-in vivo extrapolation (IVIVE)
Viera Lukacova, Simulations Plus Inc.; Michael B. Bolger, Simulations Plus Inc.; Walter Woltosz, Simulations Plus Inc.; Neil Parrott, F.Hoffmann-La Roche Ltd.; Agnčs Poirier, Hoffmann-La Roche Ltd; Thierry Lavé, Hoffmann-La Roche Ltd
Using Lentiviral Vector-Based shRNA to Silence the Expression and Function of ABC Transporter(s) in Caco-2 Cells
Chris Bode, Absorption Systems LP; Sid Bhoopathy, Absorption Systems LP; Ismael J. Hidalgo, Absorption Systems LP
Zinc Finger Nuclease (ZFN) Technology to Selectively Knockout the Expression of MDR1 and BCRP Individually and In Combination
Amanda Brinker, Sigma-Aldrich; Neetu Venkatraman, Sigma-Aldrich; Jennifer Pratt, Sigma-Aldrich; Yongling Xiao, Sigma-Aldrich; Tim Brayman, Sigma-Aldrich; Maureen Bourner, Sigma-Aldrich